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Santander is the main access city for the region. Getting to the trailhead in Santillana del Mar entails getting to Santander and then making the final leg to Santillana.
Santander and Bilbao are the most convenient airports for travel to and from the region. Santander is the closest but Bilbao has a greater selection of flights and destinations. Bilbao Airport is 100 km from Santander.
Two railway companies serve Santander:
Brittany ferries operate a service from Plymouth to Santander – the crossing takes 21 hours.
P & O operate a ferry service from Porstmouth to Bilbao – time around 34 hours
ALSA (National Express) operates a frequent service between Santander and Bilbao. The same company also runs a service between Santander and Madrid – 6 times a day with duration of around 6 hours.